Deprecated: mysql_connect(): The mysql extension is deprecated and will be removed in the future: use mysqli or PDO instead in /home/content/93/7713193/html/chandraprabhu/includes/dbconfig.php on line 20

Warning: Cannot modify header information - headers already sent by (output started at /home/content/93/7713193/html/chandraprabhu/includes/dbconfig.php:20) in /home/content/93/7713193/html/chandraprabhu/clsMsDocGenerator.php on line 281

Warning: Cannot modify header information - headers already sent by (output started at /home/content/93/7713193/html/chandraprabhu/includes/dbconfig.php:20) in /home/content/93/7713193/html/chandraprabhu/clsMsDocGenerator.php on line 283
Product Name : GLICLAZIDE                                                     
Product Description : Gliclazide is an oral hypoglycemic (anti-diabetic drug) and is classified as a sulfonylurea. Its classification has been ambiguous, as literature uses it as both a first-generation and second-generation sulfonylurea. Gliclazide was proven to protect human pancreatic beta-cells from hyperglycemia-induced apoptosis. It was also shown to have an antiatherogenic effect (preventing accumultaion of fat in arteries) in type 2 diabetes. Gliclazide selectively binds to sulfonylurea receptors (SUR-1) on the surface of the pancreatic beta-cells. It was shown to provide cardiovascular protection as it does not bind to sulfonylurea receptors (SUR-2A) in the heart.This binding effectively closes the K+ ion channels. This decreases the efflux of potassium from the cell which leads to the depolarization of the cell. This causes voltage dependent Ca++ ion channels to open increasing the Ca++ influx. The calcium can then bind to and activate calmodulin which in turn leads to exocystosis of insulin vesicles leading to insulin release.
Chemical Formula : N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide
CAS No : 21187-98-4
Molecular Formula : C15H21N3O3S
Molecular Weight : 323.412