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isoniazid manufacturer Chandraprabhu Pharma

isoniazid manufacturer


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Product Name :
ISONIAZID
Chemical Formula :
isonicotinohydrazide
CAS No :
54-85-3
Molecular Formula :
C6H7N3O 
Molecular Weight :
137.139 
isoniazid
Description :
Isoniazid also known as isonicotinylhydrazine, is an organic compound that is the first-line medication in prevention and treatment of tuberculosis. Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing. Isoniazid inhibits the P450 system.

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