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nitazoxanide manufacturer Chandraprabhu Pharma

nitazoxanide manufacturer


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Product Name :
NITAZOXANIDE
Chemical Formula :
[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate
CAS No :
55981-09-4 
Molecular Formula :
C12H9N3O5S 
Molecular Weight :
307.283
nitazoxanide
Description :
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. Nitazoxanide is a light yellow crystalline powder. It is poorly soluble in ethanol and practically insoluble in water. The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. The mechanism appears to be by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion. This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane. Nitazoxanide is a first-line choice for the treatment of illness caused by Cryptosporidium parvum or Giardia lamblia infection in immunocompetent adults and children, and is an option to be considered in the treatment of illness caused by other protozoa and/or helminths. It is used for the treatment of infectious diarrhea caused by Cryptosporidium parvum and Giardia lamblia in patients 1 year of age and older.

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