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praziquantel manufacturer Chandraprabhu Pharma

praziquantel manufacturer


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Product Name :
PRAZIQUANTEL
Chemical Formula :
(RS)-2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
CAS No :
55268-74-1
Molecular Formula :
C19H24N2O2
Molecular Weight :
312.411
praziquantel
Description :
Praziquantel is an anthelmintic effective against flatworms. Praziquantel is used to treat diseases in humans, mammals, and fish that are caused by infection with several types of internal/ gastrointestinal, and external parasites including the following: Salmon poisoning disease Hydatid disease caused by infection of various organs with larval stages of tapeworms of the genus Echinococcus Cysticercosis caused by infection of the brain and/ or muscles with the eggs and larvae of the pork tapeworm Taenia solium. Feline taeniasis caused in cats by gastrointestinal infection with adult tapeworms of the species Taenia taeniaeformis; used either alone or in combination with pyrantel pamoate Toxocariasis in cats and dogs whose gut is infected with the roundworms/ nematodes Toxocara cati or Toxocara canis respectively; use is often combined with pyrantel Schistosomiasis caused by trematodes of the genus Schistosoma. Paragonimiasis caused by infection with lung flukes, mostly of the species Paragonimus westermani. Fascioliasis ("liver rot") brought on by either Fasciola hepatica (the common liver fluke) or Fasciola gigantica Diplozoon paradoxum and other Trematoda infections of many fish species. Praziquantel increases the permeability of the membranes of schistosome cells towards calcium ions. The drug thereby induces contraction of the parasites, resulting in paralysis in the contracted state. The dying parasites are dislodged from their site of action in the host organism and may enter systemic circulation or may be destroyed by host immune reaction (phagocytosis). Additional mechanisms including focal disintegrations and disturbances of oviposition (laying of eggs) are seen in other types of sensitive parasites. "Praziquantel is active against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices (plural of "scolex"), are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces. Praziquantel is administered as a racemate, but only the (R)-enantiomer is biologically active; the enantiomers may be separated using a resolution of an amine obtained from praziquantel.

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