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stavudine manufacturer Chandraprabhu Pharma

stavudine manufacturer


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Product Name :
STAVUDINE
Chemical Formula :
1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
CAS No :
3056-17-5
Molecular Formula :
C10H12N2O4 
Molecular Weight :
224.213
stavudine
Description :
Stavudine is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it. Simultaneous use of zidovudine is not recommended, as it can inhibit the intracellular phosphorylation of stavudine. Other anti-HIV drugs do not possess this property.

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