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trimetazidine manufacturer Chandraprabhu Pharma

trimetazidine manufacturer


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Product Name :
TRIMETAZIDINE
Chemical Formula :
1-(2,3,4-trimethoxybenzyl)piperazine
CAS No :
5011-34-7
Molecular Formula :
C14H22N2O3
Molecular Weight :
266.336
trimetazidine
Description :
Trimetazidine is a drug for angina pectoris, sometimes referred to by the brand name Vastarel MR. Trimetazidine is described as the firstcytoprotective anti-ischemic agent developed and marketed by Les Laboratoires Servier (France). Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of fatty acid metabolism, also known as fatty acid oxidation inhibitor. Each tablet contains 35 mg of trimetazidine. By preserving the energy metabolism in cells exposed to hypoxia or ischemia, trimetazidine prevents a decrease in intracellular adenosine triphosphate levels, thereby ensuring the proper functioning of ionic pumps and transmembranous sodium-potassium flow whilst maintaining cellular homeostasis. It also inhibits oxidation of fatty acid in blood vessels. Trimetazidine inhibits beta-oxidation of fatty acids by blocking long-chain 3-ketoacyl-CoA thiolase, which enhances glucose oxidation.[7] In an ischaemic cell, energy obtained during glucose oxidation requires less oxygen consumption than in the beta-oxidation process. Potentiation of glucose oxidation optimizes cellular energy processes, thereby maintaining proper energy metabolism during ischaemia. By preserving energy metabolism in cells exposed to hypoxia or ischaemia, trimetazidine prevents a decrease in intracellular ATP levels, thereby ensuring the proper functioning of ionic pumps and transmembrane sodium-potassium flow whilst maintaining cellular homeostasis.

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